| 2022-08-27 12:30:00August 27, 2022 | Lancaster Black vs EMW Chiefs | 12:30:0012:30 pm | Freshman | 2022 | Walden Pond Park |
| 2022-08-27 12:30:00August 27, 2022 | CSRA Cougars vs Eden | 12:30:0012:30 pm | Freshman | 2022 | Carnegie Scranton |
| 2022-08-27 14:00:00August 27, 2022 | East Aurora vs Airlanes | 14:00:002:00 pm | Freshman | 2022 | Hamlin Park |
| 2022-08-27 14:00:00August 27, 2022 | Orchard Park vs Holland Raiders | 14:00:002:00 pm | Freshman | 2022 | Orchard Park High School Athletic Field |
| 2022-08-27 16:30:00August 27, 2022 | Alden vs Lancaster Red | 16:30:004:30 pm | Freshman | 2022 | Alden High School |
| 2022-08-31 18:00:00August 31, 2022 | Alden vs Airlanes | 18:00:006:00 pm | Freshman | 2022 | Alden Town Park |
| 2022-08-31 19:00:00August 31, 2022 | Lancaster Red vs CSRA Cougars | 19:00:007:00 pm | Freshman | 2022 | Walden Pond Park |
| 2022-08-31 19:00:00August 31, 2022 | Eden vs Lancaster Black | 19:00:007:00 pm | Freshman | 2022 | Eden Legion |
| 2022-08-31 19:00:00August 31, 2022 | TTFA Bills vs Holland Raiders | 19:00:007:00 pm | Freshman | 2022 | Kenney Field |
| 2022-09-10 11:00:00September 10, 2022 | Lancaster Red vs Eden | 11:00:0011:00 am | Freshman | 2022 | Walden Pond Park |
| 2022-09-10 12:30:00September 10, 2022 | CSRA Cougars vs Holland Raiders | 12:30:0012:30 pm | Freshman | 2022 | Carnegie Scranton |
| 2022-09-10 12:30:00September 10, 2022 | East Aurora vs TTFA Bills | 12:30:0012:30 pm | Freshman | 2022 | Hamlin Park |
| 2022-09-10 16:00:00September 10, 2022 | Orchard Park vs Lancaster Black | 16:00:004:00 pm | Freshman | 2022 | Orchard Park High School Athletic Field |
| 2022-09-10 16:30:00September 10, 2022 | Alden vs EMW Chiefs | 16:30:004:30 pm | Freshman | 2022 | Alden High School |
| 2022-09-17 12:30:00September 17, 2022 | Lancaster Red vs Orchard Park | 12:30:0012:30 pm | Freshman | 2022 | Walden Pond Park |
| 2022-09-17 12:30:00September 17, 2022 | TTFA Bills vs EMW Chiefs | 12:30:0012:30 pm | Freshman | 2022 | Kenney Field |
| 2022-09-17 12:30:00September 17, 2022 | East Aurora vs CSRA Cougars | 12:30:0012:30 pm | Freshman | 2022 | Hamlin Park |
| 2022-09-17 12:30:00September 17, 2022 | Airlanes vs Holland Raiders | 12:30:0012:30 pm | Freshman | 2022 | Stiglmeier Park |
| 2022-09-17 16:30:00September 17, 2022 | Alden vs Lancaster Black | 16:30:004:30 pm | Freshman | 2022 | Alden High School |
| 2022-09-24 12:30:00September 24, 2022 | East Aurora vs Orchard Park | 12:30:0012:30 pm | Freshman | 2022 | Hamlin Park |
| 2022-09-24 12:30:00September 24, 2022 | EMW Chiefs vs Lancaster Red | 12:30:0012:30 pm | Freshman | 2022 | Elma Centennial Park |
| 2022-09-24 12:30:00September 24, 2022 | Holland Raiders vs Eden | 12:30:0012:30 pm | Freshman | 2022 | Holland Community Center |
| 2022-09-24 12:30:00September 24, 2022 | Airlanes vs CSRA Cougars | 12:30:0012:30 pm | Freshman | 2022 | Stiglmeier Park |
| 2022-09-24 12:30:00September 24, 2022 | Lancaster Black vs TTFA Bills | 12:30:0012:30 pm | Freshman | 2022 | Walden Pond Park |
| 2022-10-01 11:00:00October 1, 2022 | Lancaster Red vs Lancaster Black | 11:00:0011:00 am | Freshman | 2022 | Walden Pond Park |
| 2022-10-01 12:30:00October 1, 2022 | TTFA Bills vs Alden | 12:30:0012:30 pm | Freshman | 2022 | Kenney Field |
| 2022-10-01 12:30:00October 1, 2022 | Airlanes vs Eden | 12:30:0012:30 pm | Freshman | 2022 | Eden Legion |
| 2022-10-01 12:30:00October 1, 2022 | Holland Raiders vs East Aurora | 12:30:0012:30 pm | Freshman | 2022 | Holland Community Center |
| 2022-10-01 16:00:00October 1, 2022 | Orchard Park vs EMW Chiefs | 16:00:004:00 pm | Freshman | 2022 | Orchard Park High School Athletic Field |
| 2022-10-08 12:30:00October 8, 2022 | TTFA Bills vs Orchard Park | 12:30:0012:30 pm | Freshman | 2022 | Kenney Field |
| 2022-10-08 12:30:00October 8, 2022 | EMW Chiefs vs Eden | 12:30:0012:30 pm | Freshman | 2022 | Elma Centennial Park |
| 2022-10-08 12:30:00October 8, 2022 | Lancaster Red vs Airlanes | 12:30:0012:30 pm | Freshman | 2022 | Walden Pond Park |
| 2022-10-08 12:30:00October 8, 2022 | CSRA Cougars vs Lancaster Black | 12:30:0012:30 pm | Freshman | 2022 | Carnegie Scranton |
| 2022-10-08 12:30:00October 8, 2022 | Alden vs East Aurora | 12:30:0012:30 pm | Freshman | 2022 | Alden High School |
| 2022-10-15 12:30:00October 15, 2022 | Eden vs Orchard Park | 12:30:0012:30 pm | Freshman | 2022 | Eden Legion |
| 2022-10-15 12:30:00October 15, 2022 | EMW Chiefs vs East Aurora | 12:30:0012:30 pm | Freshman | 2022 | Elma Centennial Park |
| 2022-10-15 12:30:00October 15, 2022 | Holland Raiders vs Alden | 12:30:0012:30 pm | Freshman | 2022 | Holland Community Center |
| 2022-10-15 12:30:00October 15, 2022 | CSRA Cougars vs TTFA Bills | 12:30:0012:30 pm | Freshman | 2022 | Carnegie Scranton |
| 2022-10-15 12:30:00October 15, 2022 | Lancaster Black vs Airlanes | 12:30:0012:30 pm | Freshman | 2022 | Walden Pond Park |
