| 2021-08-21 12:30:01August 21, 2021 | CSRA vs TTFA Buffalos | 12:30:0112:30 pm | Junior Varsity | Kenney Field |
| 2021-08-21 12:30:44August 21, 2021 | TTFA Bills vs Eden | 12:30:4412:30 pm | Junior Varsity | Eden Legion |
| 2021-08-21 14:00:18August 21, 2021 | Lancaster Wht vs Holland | 14:00:182:00 pm | Junior Varsity | Holland Community Center |
| 2021-08-21 14:30:43August 21, 2021 | AL vs Elma | 14:30:432:30 pm | Junior Varsity | Elma Centennial Park |
| 2021-08-21 14:30:50August 21, 2021 | Orchard Park vs Alden | 14:30:502:30 pm | Junior Varsity | Alden Town Park |
| 2021-08-21 14:30:51August 21, 2021 | East Aurora vs Lancaster Red | 14:30:512:30 pm | Junior Varsity | Walden Pond Park |
| 2021-08-28 12:30:32August 28, 2021 | Holland vs Lancaster Blk | 12:30:3212:30 pm | Junior Varsity | Walden Pond Park |
| 2021-08-28 14:30:05August 28, 2021 | Lancaster Red vs AL | 14:30:052:30 pm | Junior Varsity | Stiglmeier Park |
| 2021-08-28 14:30:13August 28, 2021 | Elma vs Alden | 14:30:132:30 pm | Junior Varsity | Alden Town Park |
| 2021-08-28 14:30:16August 28, 2021 | Eden vs Lancaster Wht | 14:30:162:30 pm | Junior Varsity | Walden Pond Park |
| 2021-08-28 14:30:57August 28, 2021 | CSRA vs TTFA Buffalos | 14:30:572:30 pm | Junior Varsity | Kenney Field |
| 2021-08-28 18:00:19August 28, 2021 | TTFA Buffalos vs Orchard Park | 18:00:196:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2021-09-11 14:30:26September 11, 2021 | Alden vs Lancaster Blk | 14:30:262:30 pm | Junior Varsity | Walden Pond Park |
| 2021-09-11 14:30:43September 11, 2021 | East Aurora vs Eden | 14:30:432:30 pm | Junior Varsity | Eden Legion |
| 2021-09-11 14:30:45September 11, 2021 | Orchard Park vs Elma | 14:30:452:30 pm | Junior Varsity | Elma Centennial Park |
| 2021-09-11 16:30:08September 11, 2021 | TTFA Buffalos vs Lancaster Wht | 16:30:084:30 pm | Junior Varsity | Walden Pond Park |
| 2021-09-11 18:00:32September 11, 2021 | AL vs Holland | 18:00:326:00 pm | Junior Varsity | Holland Community Center |
| 2021-09-18 14:30:00September 18, 2021 | AL vs CSRA | 14:30:002:30 pm | Junior Varsity | Carnegie Scranton |
| 2021-09-18 14:30:16September 18, 2021 | Lancaster Blk vs TTFA Bills | 14:30:162:30 pm | Junior Varsity | Kenney Field |
| 2021-09-18 14:30:29September 18, 2021 | Orchard Park vs East Aurora | 14:30:292:30 pm | Junior Varsity | Hamlin Park |
| 2021-09-18 14:30:41September 18, 2021 | TTFA Buffalos vs Holland | 14:30:412:30 pm | Junior Varsity | Holland Community Center |
| 2021-09-18 14:30:55September 18, 2021 | Elma vs Lancaster Red | 14:30:552:30 pm | Junior Varsity | Walden Pond Park |
| 2021-09-25 14:30:11September 25, 2021 | Alden vs TTFA Bills | 14:30:112:30 pm | Junior Varsity | Kenney Field |
| 2021-09-25 14:30:19September 25, 2021 | Holland vs Lancaster Red | 14:30:192:30 pm | Junior Varsity | Walden Pond Park |
| 2021-09-25 14:30:43September 25, 2021 | Lancaster Blk vs East Aurora | 14:30:432:30 pm | Junior Varsity | Hamlin Park |
| 2021-09-25 14:30:43September 25, 2021 | Orchard Park vs CSRA | 14:30:432:30 pm | Junior Varsity | Carnegie Scranton |
| 2021-09-25 14:30:57September 25, 2021 | Eden vs Elma | 14:30:572:30 pm | Junior Varsity | Elma Centennial Park |
| 2021-09-25 16:30:19September 25, 2021 | Lancaster Wht vs AL | 16:30:194:30 pm | Junior Varsity | Hamlin Park |
| 2021-10-02 12:30:03October 2, 2021 | Eden vs Lancaster Blk | 12:30:0312:30 pm | Junior Varsity | Walden Pond Park |
| 2021-10-02 14:30:08October 2, 2021 | East Aurora vs AL | 14:30:082:30 pm | Junior Varsity | Stiglmeier Park |
| 2021-10-02 14:30:34October 2, 2021 | CSRA vs Lancaster Wht | 14:30:342:30 pm | Junior Varsity | Walden Pond Park |
| 2021-10-02 14:30:57October 2, 2021 | Elma vs TTFA Buffalos | 14:30:572:30 pm | Junior Varsity | Kenney Field |
| 2021-10-02 18:00:56October 2, 2021 | TTFA Bills vs Orchard Park | 18:00:566:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2021-10-02 18:30:47October 2, 2021 | Lancaster Red vs Alden | 18:30:476:30 pm | Junior Varsity | Alden Town Park |
| 2021-10-09 12:30:45October 9, 2021 | Lancaster Blk vs CSRA | 12:30:4512:30 pm | Junior Varsity | Carnegie Scranton |
| 2021-10-09 14:30:02October 9, 2021 | Holland vs Eden | 14:30:022:30 pm | Junior Varsity | Eden Legion |
| 2021-10-09 14:30:09October 9, 2021 | East Aurora vs Alden | 14:30:092:30 pm | Junior Varsity | Alden Town Park |
| 2021-10-09 14:30:25October 9, 2021 | TTFA Bills vs Elma | 14:30:252:30 pm | Junior Varsity | Elma Centennial Park |
| 2021-10-09 14:30:55October 9, 2021 | TTFA Buffalos vs Lancaster Red | 14:30:552:30 pm | Junior Varsity | Walden Pond Park |
| 2021-10-09 16:00:56October 9, 2021 | Lancaster Wht vs Orchard Park | 16:00:564:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2021-10-16 14:30:00October 16, 2021 | Lancaster Blk vs TTFA Buffalos | 14:30:002:30 pm | Junior Varsity | Kenney Field |
| 2021-10-16 14:30:00October 16, 2021 | CSRA vs East Aurora | 14:30:002:30 pm | Junior Varsity | Hamlin Park |
| 2021-10-16 14:30:08October 16, 2021 | Alden vs Holland | 14:30:082:30 pm | Junior Varsity | Holland Community Center |
| 2021-10-16 14:30:22October 16, 2021 | Eden vs AL | 14:30:222:30 pm | Junior Varsity | Stiglmeier Park |
| 2021-10-16 16:30:28October 16, 2021 | Lancaster Wht vs TTFA Bills | 16:30:284:30 pm | Junior Varsity | Kenney Field |
| 2021-10-16 16:30:31October 16, 2021 | CSRA vs East Aurora | 16:30:314:30 pm | Junior Varsity | Hamlin Park |
| 2021-10-16 18:00:27October 16, 2021 | Lancaster Red vs Orchard Park | 18:00:276:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2021-10-23 14:30:04October 23, 2021 | Holland vs East Aurora | 14:30:042:30 pm | Junior Varsity | Hamlin Park |
| 2021-10-23 14:30:07October 23, 2021 | TTFA Buffalos vs TTFA Bills | 14:30:072:30 pm | Junior Varsity | Kenney Field |
| 2021-10-23 14:30:17October 23, 2021 | Lancaster Red vs Eden | 14:30:172:30 pm | Junior Varsity | Eden Legion |
| 2021-10-23 14:30:44October 23, 2021 | Elma vs CSRA | 14:30:442:30 pm | Junior Varsity | Carnegie Scranton |
| 2021-10-23 14:30:59October 23, 2021 | AL vs Lancaster Blk | 14:30:592:30 pm | Junior Varsity | Walden Pond Park |
| 2021-10-23 16:30:28October 23, 2021 | Alden vs Lancaster Wht | 16:30:284:30 pm | Junior Varsity | Walden Pond Park |
