| 2021-08-21 10:30:35August 21, 2021 | TTFA Bills vs Eden | 10:30:3510:30 am | Freshman | Eden Legion |
| 2021-08-21 10:30:50August 21, 2021 | CSRA vs TTFA Buffalos | 10:30:5010:30 am | Freshman | Kenney Field |
| 2021-08-21 12:30:07August 21, 2021 | East Aurora vs Lancaster Red | 12:30:0712:30 pm | Freshman | Walden Pond Park |
| 2021-08-21 12:30:43August 21, 2021 | AL vs Elma | 12:30:4312:30 pm | Freshman | Elma Centennial Park |
| 2021-08-21 12:30:55August 21, 2021 | Orchard Park vs Alden | 12:30:5512:30 pm | Freshman | Alden Town Park |
| 2021-08-28 10:30:13August 28, 2021 | Holland vs Lancaster Blk | 10:30:1310:30 am | Freshman | Walden Pond Park |
| 2021-08-28 12:30:22August 28, 2021 | CSRA vs TTFA Bills | 12:30:2212:30 pm | Freshman | Kenney Field |
| 2021-08-28 12:30:25August 28, 2021 | Lancaster Red vs AL | 12:30:2512:30 pm | Freshman | Stiglmeier Park |
| 2021-08-28 12:30:30August 28, 2021 | Elma vs Alden | 12:30:3012:30 pm | Freshman | Alden Town Park |
| 2021-08-28 16:00:35August 28, 2021 | TTFA Buffalos vs Orchard Park | 16:00:354:00 pm | Freshman | Orchard Park High School Athletic Field |
| 2021-09-01 18:00:04September 1, 2021 | Orchard Park vs Holland | 18:00:046:00 pm | Freshman | Holland Community Center |
| 2021-09-01 18:00:31September 1, 2021 | CSRA vs Eden | 18:00:316:00 pm | Freshman | Eden Legion |
| 2021-09-01 18:30:24September 1, 2021 | Alden vs TTFA Buffalos | 18:30:246:30 pm | Freshman | Kenney Field |
| 2021-09-03 18:30:42September 3, 2021 | AL vs TTFA Bills | 18:30:426:30 pm | Freshman | Kenney Field |
| 2021-09-11 12:30:09September 11, 2021 | Orchard Park vs Elma | 12:30:0912:30 pm | Freshman | Elma Centennial Park |
| 2021-09-11 12:30:10September 11, 2021 | East Aurora vs Eden | 12:30:1012:30 pm | Freshman | Eden Legion |
| 2021-09-11 12:30:46September 11, 2021 | Alden vs Lancaster Blk | 12:30:4612:30 pm | Freshman | Walden Pond Park |
| 2021-09-11 16:00:58September 11, 2021 | AL vs Holland | 16:00:584:00 pm | Freshman | Holland Community Center |
| 2021-09-18 12:30:18September 18, 2021 | Elma vs Lancaster Red | 12:30:1812:30 pm | Freshman | Walden Pond Park |
| 2021-09-18 12:30:20September 18, 2021 | AL vs CSRA | 12:30:2012:30 pm | Freshman | Carnegie Scranton |
| 2021-09-18 12:30:29September 18, 2021 | TTFA Buffalos vs Holland | 12:30:2912:30 pm | Freshman | Holland Community Center |
| 2021-09-18 12:30:44September 18, 2021 | Lancaster Blk vs TTFA Bills | 12:30:4412:30 pm | Freshman | Kenney Field |
| 2021-09-18 12:30:52September 18, 2021 | Orchard Park vs East Aurora | 12:30:5212:30 pm | Freshman | Hamlin Park |
| 2021-09-25 12:30:07September 25, 2021 | Lancaster Blk vs East Aurora | 12:30:0712:30 pm | Freshman | Hamlin Park |
| 2021-09-25 12:30:09September 25, 2021 | Orchard Park vs CSRA | 12:30:0912:30 pm | Freshman | Carnegie Scranton |
| 2021-09-25 12:30:22September 25, 2021 | Eden vs Elma | 12:30:2212:30 pm | Freshman | Elma Centennial Park |
| 2021-09-25 12:30:37September 25, 2021 | Alden vs TTFA Bills | 12:30:3712:30 pm | Freshman | Kenney Field |
| 2021-09-25 12:30:44September 25, 2021 | Holland vs Lancaster Red | 12:30:4412:30 pm | Freshman | Walden Pond Park |
| 2021-10-02 10:30:22October 2, 2021 | Eden vs Lancaster Blk | 10:30:2210:30 am | Freshman | Walden Pond Park |
| 2021-10-02 12:30:23October 2, 2021 | Elma vs TTFA Buffalos | 12:30:2312:30 pm | Freshman | Kenney Field |
| 2021-10-02 12:30:33October 2, 2021 | East Aurora vs AL | 12:30:3312:30 pm | Freshman | Stiglmeier Park |
| 2021-10-02 16:00:18October 2, 2021 | TTFA Bills vs Orchard Park | 16:00:184:00 pm | Freshman | Orchard Park High School Athletic Field |
| 2021-10-02 16:30:12October 2, 2021 | Lancaster Red vs Alden | 16:30:124:30 pm | Freshman | Alden Town Park |
| 2021-10-09 10:30:03October 9, 2021 | Lancaster Blk vs CSRA | 10:30:0310:30 am | Freshman | Carnegie Scranton |
| 2021-10-09 12:30:16October 9, 2021 | TTFA Buffalos vs Lancaster Red | 12:30:1612:30 pm | Freshman | Walden Pond Park |
| 2021-10-09 12:30:20October 9, 2021 | East Aurora vs Alden | 12:30:2012:30 pm | Freshman | Alden Town Park |
| 2021-10-09 12:30:27October 9, 2021 | Holland vs Eden | 12:30:2712:30 pm | Freshman | Eden Legion |
| 2021-10-09 12:30:55October 9, 2021 | TTFA Bills vs Elma | 12:30:5512:30 pm | Freshman | Elma Centennial Park |
| 2021-10-16 12:30:10October 16, 2021 | Alden vs Holland | 12:30:1012:30 pm | Freshman | Holland Community Center |
| 2021-10-16 12:30:15October 16, 2021 | CSRA vs East Aurora | 12:30:1512:30 pm | Freshman | Hamlin Park |
| 2021-10-16 12:30:19October 16, 2021 | Lancaster Blk vs TTFA Buffalos | 12:30:1912:30 pm | Freshman | Kenney Field |
| 2021-10-16 12:30:50October 16, 2021 | Eden vs AL | 12:30:5012:30 pm | Freshman | Stiglmeier Park |
| 2021-10-16 16:00:45October 16, 2021 | Lancaster Red vs Orchard Park | 16:00:454:00 pm | Freshman | Orchard Park High School Athletic Field |
| 2021-10-23 12:30:06October 23, 2021 | AL vs Lancaster Blk | 12:30:0612:30 pm | Freshman | Walden Pond Park |
| 2021-10-23 12:30:13October 23, 2021 | Elma vs CSRA | 12:30:1312:30 pm | Freshman | Carnegie Scranton |
| 2021-10-23 12:30:33October 23, 2021 | TTFA Buffalos vs TTFA Bills | 12:30:3312:30 pm | Freshman | Kenney Field |
| 2021-10-23 12:30:33October 23, 2021 | Holland vs East Aurora | 12:30:3312:30 pm | Freshman | Hamlin Park |
| 2021-10-23 12:30:45October 23, 2021 | Lancaster Red vs Eden | 12:30:4512:30 pm | Freshman | Eden Legion |
