| 2022-08-27 14:30:00August 27, 2022 | Lancaster Black vs EMW Chiefs | 14:30:002:30 pm | Junior Varsity | Walden Pond Park |
| 2022-08-27 14:30:00August 27, 2022 | CSRA Cougars vs Eden | 14:30:002:30 pm | Junior Varsity | Carnegie Scranton |
| 2022-08-27 16:00:00August 27, 2022 | East Aurora vs Airlanes | 16:00:004:00 pm | Junior Varsity | Hamlin Park |
| 2022-08-27 16:00:00August 27, 2022 | Orchard Park vs Holland Raiders | 16:00:004:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2022-08-27 16:00:00August 27, 2022 | Lancaster White vs TTFA Bills | 16:00:004:00 pm | Junior Varsity | Kenney Field |
| 2022-08-27 18:30:00August 27, 2022 | Alden vs Lancaster Red | 18:30:006:30 pm | Junior Varsity | Alden High School |
| 2022-08-31 18:00:00August 31, 2022 | Alden vs Airlanes | 18:00:006:00 pm | Junior Varsity | Alden Town Park |
| 2022-08-31 19:00:00August 31, 2022 | Lancaster Red vs CSRA Cougars | 19:00:007:00 pm | Junior Varsity | Walden Pond Park |
| 2022-08-31 19:00:00August 31, 2022 | Eden vs Lancaster Black | 19:00:007:00 pm | Junior Varsity | Eden Legion |
| 2022-08-31 19:00:00August 31, 2022 | TTFA Bills vs Holland Raiders | 19:00:007:00 pm | Junior Varsity | Kenney Field |
| 2022-09-10 13:00:00September 10, 2022 | Lancaster Red vs Eden | 13:00:001:00 pm | Junior Varsity | Walden Pond Park |
| 2022-09-10 14:30:00September 10, 2022 | CSRA Cougars vs Holland Raiders | 14:30:002:30 pm | Junior Varsity | Carnegie Scranton |
| 2022-09-10 14:30:00September 10, 2022 | East Aurora vs TTFA Bills | 14:30:002:30 pm | Junior Varsity | Hamlin Park |
| 2022-09-10 16:00:00September 10, 2022 | Orchard Park vs Lancaster Black | 16:00:004:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2022-09-10 17:00:00September 10, 2022 | Lancaster White vs Airlanes | 17:00:005:00 pm | Junior Varsity | Walden Pond Park |
| 2022-09-10 18:30:00September 10, 2022 | Alden vs EMW Chiefs | 18:30:006:30 pm | Junior Varsity | Alden High School |
| 2022-09-16 18:00:00September 16, 2022 | Eden vs Lancaster White | 18:00:006:00 pm | Junior Varsity | Eden Legion |
| 2022-09-17 14:30:00September 17, 2022 | Lancaster Red vs Orchard Park | 14:30:002:30 pm | Junior Varsity | Walden Pond Park |
| 2022-09-17 14:30:00September 17, 2022 | TTFA Bills vs EMW Chiefs | 14:30:002:30 pm | Junior Varsity | Kenney Field |
| 2022-09-17 14:30:00September 17, 2022 | East Aurora vs CSRA Cougars | 14:30:002:30 pm | Junior Varsity | Hamlin Park |
| 2022-09-17 14:30:00September 17, 2022 | Airlanes vs Holland Raiders | 14:30:002:30 pm | Junior Varsity | Stiglmeier Park |
| 2022-09-17 18:30:00September 17, 2022 | Alden vs Lancaster Black | 18:30:006:30 pm | Junior Varsity | Alden High School |
| 2022-09-24 14:30:00September 24, 2022 | East Aurora vs Orchard Park | 14:30:002:30 pm | Junior Varsity | Hamlin Park |
| 2022-09-24 14:30:00September 24, 2022 | EMW Chiefs vs Lancaster Red | 14:30:002:30 pm | Junior Varsity | Elma Centennial Park |
| 2022-09-24 14:30:00September 24, 2022 | Holland Raiders vs Eden | 14:30:002:30 pm | Junior Varsity | Holland Community Center |
| 2022-09-24 14:30:00September 24, 2022 | Airlanes vs CSRA Cougars | 14:30:002:30 pm | Junior Varsity | Stiglmeier Park |
| 2022-09-24 14:30:00September 24, 2022 | Lancaster Black vs TTFA Bills | 14:30:002:30 pm | Junior Varsity | Walden Pond Park |
| 2022-09-24 16:30:00September 24, 2022 | Lancaster White vs Alden | 16:30:004:30 pm | Junior Varsity | Walden Pond Park |
| 2022-10-01 13:00:00October 1, 2022 | Lancaster Red vs Lancaster Black | 13:00:001:00 pm | Junior Varsity | Walden Pond Park |
| 2022-10-01 14:30:00October 1, 2022 | TTFA Bills vs Alden | 14:30:002:30 pm | Junior Varsity | Kenney Field |
| 2022-10-01 14:30:00October 1, 2022 | Airlanes vs Eden | 14:30:002:30 pm | Junior Varsity | Eden Legion |
| 2022-10-01 14:30:00October 1, 2022 | Holland Raiders vs East Aurora | 14:30:002:30 pm | Junior Varsity | Holland Community Center |
| 2022-10-01 15:00:00October 1, 2022 | Lancaster White vs CSRA Cougars | 15:00:003:00 pm | Junior Varsity | Walden Pond Park |
| 2022-10-01 18:00:00October 1, 2022 | Orchard Park vs EMW Chiefs | 18:00:006:00 pm | Junior Varsity | Orchard Park High School Athletic Field |
| 2022-10-08 14:30:00October 8, 2022 | TTFA Bills vs Orchard Park | 14:30:002:30 pm | Junior Varsity | Kenney Field |
| 2022-10-08 14:30:00October 8, 2022 | EMW Chiefs vs Eden | 14:30:002:30 pm | Junior Varsity | Elma Centennial Park |
| 2022-10-08 14:30:00October 8, 2022 | Lancaster Red vs Airlanes | 14:30:002:30 pm | Junior Varsity | Walden Pond Park |
| 2022-10-08 14:30:00October 8, 2022 | CSRA Cougars vs Lancaster Black | 14:30:002:30 pm | Junior Varsity | Carnegie Scranton |
| 2022-10-08 14:30:00October 8, 2022 | Alden vs East Aurora | 14:30:002:30 pm | Junior Varsity | Alden High School |
| 2022-10-08 16:30:00October 8, 2022 | Holland Raiders vs Lancaster White | 16:30:004:30 pm | Junior Varsity | Holland Community Center |
| 2022-10-15 14:30:00October 15, 2022 | Eden vs Orchard Park | 14:30:002:30 pm | Junior Varsity | Eden Legion |
| 2022-10-15 14:30:00October 15, 2022 | EMW Chiefs vs East Aurora | 14:30:002:30 pm | Junior Varsity | Elma Centennial Park |
| 2022-10-15 14:30:00October 15, 2022 | Holland Raiders vs Alden | 14:30:002:30 pm | Junior Varsity | Holland Community Center |
| 2022-10-15 14:30:00October 15, 2022 | CSRA Cougars vs TTFA Bills | 14:30:002:30 pm | Junior Varsity | Carnegie Scranton |
| 2022-10-15 14:30:00October 15, 2022 | Lancaster Black vs Airlanes | 14:30:002:30 pm | Junior Varsity | Walden Pond Park |
| 2022-10-15 16:30:00October 15, 2022 | Lancaster White vs Lancaster Red | 16:30:004:30 pm | Junior Varsity | Walden Pond Park |
