| 2021-08-21 10:30:13August 21, 2021 | East Aurora vs Lancaster Red | 10:30:1310:30 am | Pee Wee | Walden Pond Park |
| 2021-08-21 10:30:45August 21, 2021 | AL vs Elma | 10:30:4510:30 am | Pee Wee | Elma Centennial Park |
| 2021-08-21 10:30:57August 21, 2021 | Orchard Park vs Alden | 10:30:5710:30 am | Pee Wee | Alden Town Park |
| 2021-08-21 18:00:47August 21, 2021 | CSRA vs Holland | 18:00:476:00 pm | Pee Wee | Holland Community Center |
| 2021-08-24 18:30:07August 24, 2021 | Eden vs TTFA Bills | 18:30:076:30 pm | Pee Wee | Kenney Field |
| 2021-08-27 18:00:53August 27, 2021 | Eden vs Holland | 18:00:536:00 pm | Pee Wee | Holland Community Center |
| 2021-08-28 10:30:38August 28, 2021 | Elma vs Alden | 10:30:3810:30 am | Pee Wee | Alden Town Park |
| 2021-08-28 10:30:43August 28, 2021 | CSRA vs TTFA Bills | 10:30:4310:30 am | Pee Wee | Kenney Field |
| 2021-08-28 10:30:56August 28, 2021 | Lancaster Red vs AL | 10:30:5610:30 am | Pee Wee | Stiglmeier Park |
| 2021-08-28 14:00:47August 28, 2021 | East Aurora vs Orchard Park | 14:00:472:00 pm | Pee Wee | Orchard Park High School Athletic Field |
| 2021-09-11 10:30:00September 11, 2021 | Alden vs Lancaster Red | 10:30:0010:30 am | Pee Wee | Walden Pond Park |
| 2021-09-11 10:30:20September 11, 2021 | Orchard Park vs Elma | 10:30:2010:30 am | Pee Wee | Elma Centennial Park |
| 2021-09-11 10:30:34September 11, 2021 | East Aurora vs Eden | 10:30:3410:30 am | Pee Wee | Eden Legion |
| 2021-09-11 14:00:23September 11, 2021 | AL vs Holland | 14:00:232:00 pm | Pee Wee | Holland Community Center |
| 2021-09-18 10:30:07September 18, 2021 | Eden vs TTFA Bills | 10:30:0710:30 am | Pee Wee | Kenney Field |
| 2021-09-18 10:30:18September 18, 2021 | Orchard Park vs East Aurora | 10:30:1810:30 am | Pee Wee | Hamlin Park |
| 2021-09-18 10:30:23September 18, 2021 | AL vs CSRA | 10:30:2310:30 am | Pee Wee | Carnegie Scranton |
| 2021-09-18 10:30:41September 18, 2021 | Elma vs Lancaster Red | 10:30:4110:30 am | Pee Wee | Walden Pond Park |
| 2021-09-18 10:30:53September 18, 2021 | Alden vs Holland | 10:30:5310:30 am | Pee Wee | Holland Community Center |
| 2021-09-25 10:30:06September 25, 2021 | Holland vs Lancaster Red | 10:30:0610:30 am | Pee Wee | Walden Pond Park |
| 2021-09-25 10:30:32September 25, 2021 | AL vs East Aurora | 10:30:3210:30 am | Pee Wee | Hamlin Park |
| 2021-09-25 10:30:36September 25, 2021 | Orchard Park vs CSRA | 10:30:3610:30 am | Pee Wee | Carnegie Scranton |
| 2021-09-25 10:30:43September 25, 2021 | Eden vs Elma | 10:30:4310:30 am | Pee Wee | Elma Centennial Park |
| 2021-09-25 10:30:57September 25, 2021 | Alden vs TTFA Bills | 10:30:5710:30 am | Pee Wee | Kenney Field |
| 2021-10-02 10:30:02October 2, 2021 | East Aurora vs AL | 10:30:0210:30 am | Pee Wee | Stiglmeier Park |
| 2021-10-02 10:30:38October 2, 2021 | Elma vs CSRA | 10:30:3810:30 am | Pee Wee | Kenney Field |
| 2021-10-02 14:00:44October 2, 2021 | TTFA Bills vs Orchard Park | 14:00:442:00 pm | Pee Wee | Orchard Park High School Athletic Field |
| 2021-10-02 14:30:30October 2, 2021 | Lancaster Red vs Alden | 14:30:302:30 pm | Pee Wee | Alden Town Park |
| 2021-10-09 10:30:04October 9, 2021 | East Aurora vs Alden | 10:30:0410:30 am | Pee Wee | Alden Town Park |
| 2021-10-09 10:30:17October 9, 2021 | TTFA Bills vs Elma | 10:30:1710:30 am | Pee Wee | Elma Centennial Park |
| 2021-10-09 10:30:43October 9, 2021 | Holland vs Eden | 10:30:4310:30 am | Pee Wee | Eden Legion |
| 2021-10-09 14:00:24October 9, 2021 | CSRA vs Orchard Park | 14:00:242:00 pm | Pee Wee | Orchard Park High School Athletic Field |
| 2021-10-16 10:30:20October 16, 2021 | Elma vs TTFA Bills | 10:30:2010:30 am | Pee Wee | Kenney Field |
| 2021-10-16 10:30:20October 16, 2021 | Eden vs AL | 10:30:2010:30 am | Pee Wee | Stiglmeier Park |
| 2021-10-16 10:30:40October 16, 2021 | Alden vs Holland | 10:30:4010:30 am | Pee Wee | Holland Community Center |
| 2021-10-16 10:30:44October 16, 2021 | CSRA vs East Aurora | 10:30:4410:30 am | Pee Wee | Hamlin Park |
| 2021-10-16 14:00:02October 16, 2021 | Lancaster Red vs Orchard Park | 14:00:022:00 pm | Pee Wee | Orchard Park High School Athletic Field |
| 2021-10-23 10:30:03October 23, 2021 | Holland vs East Aurora | 10:30:0310:30 am | Pee Wee | Hamlin Park |
| 2021-10-23 10:30:04October 23, 2021 | Orchard Park vs TTFA Bills | 10:30:0410:30 am | Pee Wee | Kenney Field |
| 2021-10-23 10:30:13October 23, 2021 | Lancaster Red vs Eden | 10:30:1310:30 am | Pee Wee | Eden Legion |
| 2021-10-23 10:30:35October 23, 2021 | AL vs Alden | 10:30:3510:30 am | Pee Wee | Walden Pond Park |
| 2021-10-23 10:30:40October 23, 2021 | Elma vs CSRA | 10:30:4010:30 am | Pee Wee | Carnegie Scranton |
